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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
15/09/2021 |
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Data da última atualização: |
15/09/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PEREIRA, H. P.; VERARDO, L. L.; WELLER, M. M. D. C. A.; SBARDELLA, A. P.; MUNARI, D. P.; DAIBERT, R. M. de P.; CARVALHO, W. A.; MACHADO, M. A.; MARTINS, M. F. |
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Afiliação: |
HYAGO PASSE PEREIRA, Universidade Federal de Juiz de Fora; LUCAS LIMA VERARDO, Universidade Federal dos Vales do Jequitinhonha e Mucuri; MAYARA MORENA DEL CAMBRE AMARAL WELLER, Universidade Federal do Espírito Santo; ANA PAULA SBARDELLA, Universidade Estadual Paulista Júlio de Mesquita Filho; DANÍSIO PRADO MUNARI, Universidade Estadual Paulista Júlio de Mesquita Filho; RAQUEL MORAIS DE PAIVA DAIBERT; WANESSA ARAUJO CARVALHO, CNPGL; MARCO ANTONIO MACHADO, CNPGL; MARTA FONSECA MARTINS, CNPGL. |
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Título: |
Going further post-RNA-seq: in silico functional analyses revealing candidate genes and regulatory elements related to mastitis in dairy cattle. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Journal of Dairy Research, v. 88, p. 286-292, 2021. |
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Idioma: |
Inglês |
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Conteúdo: |
This study aimed to obtain a better understanding of the regulatory genes and molecules involved in the development of mastitis. For this purpose, the transcription factors (TF) and MicroRNAs (miRNA) related to differentially expressed genes previously found in extracorporeal udders infected with Streptococcus agalactiae were investigated. The Gene-TF network highlighted LOC515333, SAA3, CD14, NFKBIA, APOC2 and LOC100335608 and genes that encode the most representative transcription factors STAT3, PPARG, EGR1 and NFKB1 for infected udders. In addition, it was possible to highlight, through the analysis of the gene-miRNA network, genes that could be post-transcriptionally regulated by miRNAs, such as the relationship between the CCL5 gene and the miRNA bta-miR-363. Overall, our data demonstrated genes and regulatory elements (TF and miRNA) that can play an important role in mastitis resistance. The results provide new insights into the first functional pathways and the network of genes that orchestrate the innate immune responses to infection by Streptococcus agalactiae. Our results will increase the general knowledge about the gene networks, transcription factors and miRNAs involved in fighting intramammary infection and maintaining tissue during infection and thus enable a better understanding of the pathophysiology of mastitis. |
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Thesagro: |
Bovino; Gado Leiteiro; Mamite. |
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Thesaurus Nal: |
Mastitis; MicroRNA; Transcription factors. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02222naa a2200289 a 4500
001 2134430
005 2021-09-15
008 2021 bl uuuu u00u1 u #d
100 1 $aPEREIRA, H. P.
245 $aGoing further post-RNA-seq$bin silico functional analyses revealing candidate genes and regulatory elements related to mastitis in dairy cattle.$h[electronic resource]
260 $c2021
520 $aThis study aimed to obtain a better understanding of the regulatory genes and molecules involved in the development of mastitis. For this purpose, the transcription factors (TF) and MicroRNAs (miRNA) related to differentially expressed genes previously found in extracorporeal udders infected with Streptococcus agalactiae were investigated. The Gene-TF network highlighted LOC515333, SAA3, CD14, NFKBIA, APOC2 and LOC100335608 and genes that encode the most representative transcription factors STAT3, PPARG, EGR1 and NFKB1 for infected udders. In addition, it was possible to highlight, through the analysis of the gene-miRNA network, genes that could be post-transcriptionally regulated by miRNAs, such as the relationship between the CCL5 gene and the miRNA bta-miR-363. Overall, our data demonstrated genes and regulatory elements (TF and miRNA) that can play an important role in mastitis resistance. The results provide new insights into the first functional pathways and the network of genes that orchestrate the innate immune responses to infection by Streptococcus agalactiae. Our results will increase the general knowledge about the gene networks, transcription factors and miRNAs involved in fighting intramammary infection and maintaining tissue during infection and thus enable a better understanding of the pathophysiology of mastitis.
650 $aMastitis
650 $aMicroRNA
650 $aTranscription factors
650 $aBovino
650 $aGado Leiteiro
650 $aMamite
700 1 $aVERARDO, L. L.
700 1 $aWELLER, M. M. D. C. A.
700 1 $aSBARDELLA, A. P.
700 1 $aMUNARI, D. P.
700 1 $aDAIBERT, R. M. de P.
700 1 $aCARVALHO, W. A.
700 1 $aMACHADO, M. A.
700 1 $aMARTINS, M. F.
773 $tJournal of Dairy Research$gv. 88, p. 286-292, 2021.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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